Gum Arabic supplementation prevents loss of learning and memory through stimulation of mitochondrial function in the hippocampus of type 2 diabetic rats

The aim was to determine whether gum Arabic (GA) supplementation prevents cognitive decline in type 2 diabetes, through stimulation of mitochondrial function the hippocampus. Type diabetic rats and controls were assigned following groups for 16 weeks: Control + Water; GA 10% w/v; Diabetes w/v. Latency water maze shorter compared Water (P < 0.05). group had a higher expression density per cell peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) A similar trend observed ATP synthase β-subunit (ATPB). Number PGC-1α positive cells diabetes control (p prevented learning memory loss diabetes. This associated with greater PGC-1a ATBP protein